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Rubone

SKU T24744-1 mg Category Natural Product Brand: TargetMol

Price range: 98 CAD through 1,227 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– Rubone (2′-Hydroxy-2,4,4′,5,6′-pentamethoxychalcone), a natural product and a modulator of miR-34a (microRNA-34), upregulates miR-34a expression in a p53-dependent manner, which in turn downregulates the expression of downstream targets Bcl-2, cyclin-D1, CDK6, SIRT1, and FOXP1, thereby inhibiting tumor growth and reversal of hepatocellular carcinoma (HCC) and chemoresistance in prostate cancer.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T24744

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C20H22O7

References

– Wen D, Peng Y, Lin F, Singh RK, Mahato RI. Micellar Delivery of miR-34a Modulator Rubone and Paclitaxel in Resistant Prostate Cancer. Cancer Res. 2017 Jun 15;77(12):3244-3254. doi: 10.1158/0008-5472.CAN-16-2355. Epub 2017 Apr 20. PubMed PMID: 28428276; PubMed Central PMCID: PMC5673080.

CAS Number

– 73694-15-2

Molecular Weight

– C20H22O7

Compound Purity

– 0.9892

SMILES

– C(=C/C(=O)C1=C(OC)C=C(OC)C=C1O)C2=C(OC)C=C(OC)C(OC)=C2

Pathway

– Chromatin/Epigenetic

Product type

– Natural Product

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.