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Rigosertib

SKU T16750-2 mg Category Small Compound Brand: TargetMol

Price range: 54 CAD through 155 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– Rigosertib (ON-01910) is a selective, non-ATP-competitive PLK1 inhibitor (IC50: 9 nM) and multi-kinase inhibitor. As a selective anti-cancer agent, Rigosertib induces apoptosis by inhibiting the PI3 kinase/Akt pathway, promotes histone H2AX phosphorylation, and induces G2/M arrest in the cell cycle.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T16750

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C21H25NO8S

References

– Xu F, et al. Rigosertib as a selective anti-tumor agent can ameliorate multiple dysregulated signalingtransduction pathways in high-grade myelodysplastic syndrome. Sci Rep. 2014 Dec 4;4:7310.

CAS Number

– 592542-59-1

Molecular Weight

– C21H25NO8S

Compound Purity

– 0.9953

SMILES

– C(=C/S(CC1=CC(NCC(O)=O)=C(OC)C=C1)(=O)=O)C2=C(OC)C=C(OC)C=C2OC

Target

– Others

Pathway

– Cell Cycle/Checkpoint|||Angiogenesis|||Cytoskeletal Signaling|||Apoptosis|||Tyrosine Kinase/Adaptors|||PI3K/Akt/mTOR signaling

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.