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(Rac)-Indoximod
$55 – $88
Products Details
Product Description
– (Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes[1].
Web ID
– HY-133897
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C12H14N2O2
References
– [1]Jun-Won Lee,et al. Co-treatment with interferon-γ and 1-methyl tryptophan ameliorates cardiac fibrosis through cardiac myofibroblasts apoptosis. Mol Cell Biochem. 2019 Aug;458(1-2):197-205.
CAS Number
– 26988-72-7
Molecular Weight
– 218.25
Compound Purity
– 98.13
SMILES
– NC(CC1=CN(C)C2=C1C=CC=C2)C(O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– 0.1 M NaOH : 10 mg/mL (ultrasonic)|DMSO : 4.76 mg/mL (ultrasonic;warming;adjust pH to 4 with HCl;heat to 60°C)
Target
– Apoptosis;Indoleamine 2,3-Dioxygenase (IDO)
Isoform
– IDO
Pathway
– Apoptosis;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
