Download Files:
Products Details
Product Description
– (R)-V-0219 is an enantiomer of V-0219 (HY-143312). V-0219 is an orally active and positive allosteric modulator (PAM) of the GLP Receptor-1 (GLP-1R). (R)-V-0219 activates calcium fluxes in HEK cells stably expressing hGLP-1R[1].
Web ID
– HY-143312B
Shipping
– Room temperature
Molecular Formula
– C20H25F3N4O2
References
– [1]Decara JM, et al. Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for “Diabesity”. J Med Chem. 2022 Apr 14;65(7):5449-5461.
Molecular Weight
– 410.43
SMILES
– FC(C1=CC=C(C2=NOC(CN3C[C@@H](CN4CCOCC4)CCC3)=N2)C=C1)(F)F
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– GLP Receptor
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
