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Products Details
Product Description
– Tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in mice in vivo.
For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.
Web ID
– TP1946
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C38H43N5O8
References
– Hagiwara et al (1992) Studies on neurokinin antagonists. 1. The design of novel tripeptides possessing the glutaminyl-D-tryptophylphenylalanine sequence as substance P antagonists. J.Med.Chem. 35 2015 PMID:
CAS Number
– 126088-82-2
Molecular Weight
– C38H43N5O8
SMILES
– C([C@H](C(N[C@@H](CC1=CC=CC=C1)C(OCC2=CC=CC=C2)=O)=O)NC([C@@H](NC(OC(C)(C)C)=O)CCC(N)=O)=O)C=3C=4C(N(C=O)C3)=CC=CC4
Product type
– Peptide
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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