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Product Description
– Quinacrine hydrochloride hydrate (Mepacrine hydrochloride hydrate) is an antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine hydrochloride hydrate suppresses NF-κB and activates p53 signaling, which results in the induction of the apoptosis[1].
Web ID
– HY-13735B
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C23H36Cl3N3O3
References
– [1]Xiaoyang Wu, et al. Quinacrine Inhibits Cell Growth and Induces Apoptosis in Human Gastric Cancer Cell Line SGC-7901. Curr Ther Res Clin Exp. 2012 Feb;73(1-2):52-64.|[2]Anna Eriksson, et al. Towards repositioning of quinacrine for treatment of acute myeloid leukemia – Promising synergies and in vivo effects. Leuk Res. 2017 Dec;63:41-46.
CAS Number
– 6151-30-0
Molecular Weight
– 508.91
SMILES
– CC(NC1=C(C=C(OC)C=C2)C2=NC3=CC(Cl)=CC=C31)CCCN(CC)CC.[H]Cl.[H]Cl.[H]O[H].[H]O[H]
Clinical Information
– Phase 2
Research Area
– Cancer; Infection
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Autophagy;Mitophagy;Parasite
Isoform
– Plasmodium
Pathway
– Anti-infection;Apoptosis;Autophagy
Product type
– Reference compound
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