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QNZ

SKU T6204-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 58 CAD through 826 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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2 mg 1 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– QNZ (EVP4593) (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T6204

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C22H20N4O

Citations

– 1. Lai X, Wang M, Zhu Y, et al. ZnO NPs delay the recovery of psoriasis-like skin lesions through promoting inflammation and keratinocyte apoptosis via nuclear translocation of phosphorylated NF-κB p65 and cysteine deficiency. Journal of Hazardous Materials. 2020: 124566 2. Hu Q, Du H, Ma G, et al. Purification, identification and functional characterization of an immunomodulatory protein from Pleurotus eryngii. Food & Function. 2018, 9(7): 3764-3775 3. Zhang R, Tang L, Wang Y, et al.A Dendrimer Peptide (KK2DP7) Delivery System with Dual Functions of Lymph Node Targeting and Immune Adjuvants as a General Strategy for Cancer Immunotherapy.Advanced Science.2023: 2300116. 4. Tan Z, Pan K, Sun M, et al.CCKBR+ cancer cells contribute to the intratumor heterogeneity of gastric cancer and confer sensitivity to FOXO inhibition.Cell Death & Differentiation.2024: 1-16. 5. He Q, Zhang Y, Li W, et al.Inhibition of PRMT5 moderately suppresses prostate cancer growth in vivo but enhances its response to immunotherapy.Cancer Letters.2024: 217214. 6. Cao T, Li A Q, Zhang Y, et al.Norwogonin attenuates LPS-induced acute lung injury through inhibiting Src/AKT1/NF-κB signaling pathway.Phytomedicine.2025: 156432.

References

– Tobe M, et al. Bioorg Med Chem, 2003, 11(3), 383-391.

CAS Number

– 545380-34-5

Molecular Weight

– C22H20N4O

Compound Purity

– 0.9986

SMILES

– Nc1ccc2ncnc(NCCc3ccc(Oc4ccccc4)cc3)c2c1

Pathway

– Apoptosis|||NF-κB

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.