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Purmorphamine
$99 – $792
Products Details
Product Description
– Purmorphamine is a smoothened/Smo receptor agonist with an EC50 of 1 μM.
Web ID
– HY-15108
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C31H32N6O2
Citations
– Biochem Biophys Res Commun. 12 August 2021.|Burns Trauma. 2019 Sep 23;7:29.|Cancer Med. 2018 Nov;7(11):5704-5715.|J Exp Clin Cancer Res. 2018 Nov 27;37(1):287. |Med Oncol. 2021 Mar 17;38(4):41.|Mil Med Res. 2020 Nov 1;7(1):52.|Mil Med Res. 2020 Sep 6;7(1):42. |Oncol Lett. 2019 Sep;18(3):3081-3091.|Patent. US20180263995A1.|Pharmacol Res. 2021 Jan 26;105460.|Life Sci. 2023 Jul 29;329:121990.
References
– [1]Beloti MM, et al. Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells. Cell Biol Int. 2005 Jul;29(7):537-41.. . . .|[2]Gu D, et al. A role for transcription factor STAT3 signaling in oncogene smoothened-driven carcinogenesis. J Biol Chem. 2012 Nov 2;287(45):38356-66.|[3]Beloti MM, et al. Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells. Cell Biol Int. 2005 Jul;29(7):537-41.
CAS Number
– 483367-10-8
Molecular Weight
– 520.62
Compound Purity
– 99.89
SMILES
– N1(C2=CC=C(NC3=NC(OC4=CC=CC5=C4C=CC=C5)=NC6=C3N=CN6C7CCCCC7)C=C2)CCOCC1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease; Cancer
Solubility
– DMSO : 33.33 mg/mL (ultrasonic)
Target
– Autophagy;Smo
Pathway
– Autophagy;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
