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Potassium 1H-indol-3-yl sulfate

SKU T4938-5 mg Category Natural Product Brand: TargetMol

Price range: 54 CAD through 549 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) is an agonist for the human Aryl Hydrocarbon Receptor (AhR), a key regulator of immune-inflammatory conditions. A metabolite of tryptophan derived from dietary protein, it is produced by intestinal bacteria and metabolized in the liver. In chronic kidney disease patients with impaired renal function, it accumulates in serum as a uremic toxin, inducing oxidative stress and accelerating disease progression. At 250 μM, it activates NF-Κb, promoting TGF-β1 and Smad3 expression in rat proximal tubular cells, which is associated with profibrotic activity.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T4938

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C8H6KNO4S

References

– Zgoda-Pols J R , Chowdhury S , Wirth M , et al. Metabolomics analysis reveals elevation of 3-indoxyl sulfate in plasma and brain during chemically-induced acute kidney injury in mice: Investigation of nicotinic acid receptor agonists[J]. Toxicology & Applied Pharmacology, 2011, 255(1):48-56.

CAS Number

– 2642-37-7

Molecular Weight

– C8H6KNO4S

Compound Purity

– 0.9971

SMILES

– [K+].[O-]S(=O)(=O)Oc1c[nH]c2ccccc12

Pathway

– Immunology/Inflammation|||Metabolism

Product type

– Natural Product

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.