Download Files:

Pinometostat

SKU T3099-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 54 CAD through 130 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

2 mg 1 mL * 10 mM (in DMSO)10 mg 5 mg 50 mg

Clear

Products Details

Product Description

– Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor (Ki=80 pM). Pinometostat has antitumor activity and can be used in experiments to study a variety of leukemia treatments.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T3099

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C30H42N8O3

Citations

– 1. Yu S, Zhou C, He J, et al. BMP4 drives primed to naïve transition through PGC-like state. Nature Communications. 2022, 13(1): 1-15 2. Chen R, Xie W, Cai B, et al. Establishment and Identification of a CiPSC Lineage Reprogrammed from FSP-tdTomato Mouse Embryonic Fibroblasts (MEFs). Stem Cells International. 2018 Dec 25;2018:5965727 3. Zhao X, Li X, Sun H, et al.Dot1l cooperates with Npm1 to repress endogenous retrovirus MERVL in embryonic stem cells.Nucleic Acids Research.2023: gkad640. 4. Ma Z, Huang X, Kuang J, et al.Cpt1a Drives primed-to-naïve pluripotency transition through lipid remodeling.Communications Biology.2024, 7(1): 1223.

References

– Robert A. Protein methyltransferases in cancer. AACR Annual Meeting, 2013.

CAS Number

– 1380288-87-8

Molecular Weight

– C30H42N8O3

Compound Purity

– 0.9986

SMILES

– O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](CN(C(C)C)[C@H]4C[C@@H](CCC=5NC=6C(N5)=CC=C(C(C)(C)C)C6)C4)[C@H]1O

Pathway

– Chromatin/Epigenetic

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.