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Products Details
Product Description
– Pim-1 kinase inhibitor 5 (Compound 4c) is a Pim-1 kinase inhibitor (IC50: 0.61 μM). Pim-1 kinase inhibitor 5 shows cytotoxicity against cancer cells, with IC50s of 6.95-20.19 μM for HepG2, MCF-7, PC3, and HCT-116 cells[1].
Web ID
– HY-149995
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C22H13Cl2N3O
References
– [1]Mansour B, et al. Cyanopyridinone- and Cyanopyridine-Based Cancer Cell Pim-1 Inhibitors: Design, Synthesis, Radiolabeling, Biodistribution, and Molecular Modeling Simulation. ACS Omega. 2023 May 24;8(22):19351-19366.
CAS Number
– 2928606-67-9
Molecular Weight
– 406.26
SMILES
– ClC(C(C1=CC(C2=CC=C(OC)C=C2)=NC(Cl)=C1C#N)=C3)=NC4=C3C=CC=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Pim
Pathway
– JAK/STAT Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
