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Pexidartinib
Price range: 64 CAD through 590 CAD
Products Details
Product Description
– Pexidartinib (PLX-3397) is a capsule containing a small-molecule receptor tyrosine kinase (RTK) inhibitor targeting KIT, CSF1R, and FLT3, with potential antineoplastic activity.
Web ID
– T2115
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C20H15ClF3N5
Citations
– 1. Fan K, Li Y, Wang H, et al. Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior. Cell. 2019, 179(4): 864-879. e19.
2. Xu F, Han L, Wang Y, et al.Prolonged anesthesia induces neuroinflammation and complement-mediated microglial synaptic elimination involved in neurocognitive dysfunction and anxiety-like behaviors.BMC medicine.2023, 21(1): 1-27.
3. Wang Q, Zeng F, Fang C, et al.Galectin-3 alleviates demyelination by modulating microglial anti-inflammatory polarization through PPARγ-CD36 axis.Brain Research.2024: 149106.
4. Wang H, Peng X, Wu K, et al.Microglia contribute to nociception via CSF‐1R signaling pathway in rat orofacial carcinoma.Oral Diseases..2024
References
– Fujiwara T, et al. CSF1/CSF1R Signaling Inhibitor Pexidartinib (PLX3397) Reprograms Tumor-Associated Macrophages and Stimulates T-cell Infiltration in the Sarcoma Microenvironment. Mol Cancer Ther. 2021 Aug;20(8):1388-1399.
CAS Number
– 1029044-16-3
Molecular Weight
– C20H15ClF3N5
Compound Purity
– 0.9921
SMILES
– FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1
Pathway
– Angiogenesis|||Tyrosine Kinase/Adaptors|||Apoptosis
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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