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PCI-33380
$350 – $1,900
Products Details
Product Description
– PCI-33380 is an irreversible and selective Bruton’s Tyrosine Kinase (BTK) inhibitor (fluorescent probe).
Web ID
– HY-100335
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Molecular Formula
– C46H52BF2N11O3
References
– [1]Zuo Y, et al. A novel 2,5-diaminopyrimidine-based affinity probe for Bruton’s tyrosine kinase. Sci Rep. 2015 Nov 4;5:16136.|[2]Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80.
CAS Number
– 1022899-36-0
Molecular Weight
– 855.78
Compound Purity
– 98.0
SMILES
– NC1=C(C(C2=CC=C(OC3=CC=CC=C3)C=C2)=NN4C(CCC5)CN5C(/C=C/CN6CCN(CCNC(CCC7=CC=C(C=C(C(C)=C8)[N]9=C8C)[N-]7[B+3]9([F-])[F-])=O)CC6)=O)C4=NC=N1
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– DMSO : ≥ 50 mg/mL
Target
– Btk
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
