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Oxaliplatin

SKU T0164-5 mg Category Small Compound Brand: TargetMol

Price range: 48 CAD through 222 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– Oxaliplatin (L-OHP) is a DNA alkylating agent, an inhibitor of DNA synthesis. Oxaliplatin causes DNA cross-linking damage, preventing DNA replication and transcription and leading to cell death. Oxaliplatin induces autophagy.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T0164

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C8H14N2O4Pt

Citations

– 1. Chao S, Zhang F, Yan H, et al.Targeting intratumor heterogeneity suppresses colorectal cancer chemoresistance and metastasis.EMBO reports.2023: e56416. 2. Jiang Y, Feng Y, Huang J, et al.LAD1 promotes malignant progression by diminishing ubiquitin-dependent degradation of vimentin in gastric cancer.Journal of Translational Medicine.2023, 21(1): 1-15. 3. Feng Y, Cao Z, Xu A, et al.Evaluation of toxicity and mutagenicity of oxaliplatin on germ cells in an alternative in vivo model Caenorhabditis elegans.Food and Chemical Toxicology.2023: 113902. 4. Yu Y, Wu T, Zhang X, et al.Regorafenib activates oxidative stress by inhibiting SELENOS and potentiates oxaliplatin-induced cell death in colon cancer cells.European Journal of Pharmacology.2023: 175986. 5. Zhang Z, Ye J, Liu X, et al.Huangqi Guizhi Wuwu decoction alleviates oxaliplatin-induced peripheral neuropathy via the gut-peripheral nerve axis.Chinese Medicine.2023, 18(1): 1-15. 6. Feng W Q, Zhang Y C, Gao H, et al.FOXD1 promotes chemotherapy resistance by enhancing cell stemness in colorectal cancer through β‑catenin nuclear localization.Oncology Reports.2023, 50(1): 1-14. 7. Li J, Lv J, Chen Y, et al.Tumor suppressor circPDE4D inhibits the progression of colorectal cancer and regulates oxaliplatin chemoresistance.Gene.2023: 147323. 8. Zhao L, Liu S, Zhang X, et al.Satellite glial cell-secreted exosomes after in-vitro oxaliplatin treatment presents a pro-nociceptive effect for dorsal root ganglion neurons and induce mechanical hypersensitivity in naïve mice.Molecular and Cellular Neuroscience.2023: 103881. 9. Liu M, Mai J W, Luo D X, et al.NFATc2-dependent Epigenetic Downregulation of the TSC2/Beclin-1 Pathway is Involved in Neuropathic Pain Induced by Oxaliplatin.Molecular Pain.2023: 17448069231158289. 10. Glorieux C, Xia X, You X, et al. Cisplatin and gemcitabine exert opposite effects on immunotherapy with PD-1 antibody in K-ras-driven cancer. Journal of Advanced Research. 2021

References

– Nannizzi S, et al. Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines. Cancer Chemother Pharmacol. 2010 Aug;66(3):547-58.

CAS Number

– 61825-94-3

Molecular Weight

– C8H14N2O4Pt

Compound Purity

– 0.9901

SMILES

– O=C1O[Pt]OC1=O.N[C@@H]1CCCC[C@H]1N

Target

– AChR

Pathway

– DNA Damage/DNA Repair|||Autophagy|||Cell Cycle/Checkpoint

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.