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NSC 66811
$38 – $88
Products Details
Product Description
– NSC 66811 is a MDM2-p53 inhibitor, with a Ki of 120 nM for binding to MDM2[1].
Web ID
– HY-14967
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C23H20N2O
References
– [1]Yipin Lu, et al. Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. J Med Chem. 2006 Jun 29;49(13):3759-62.|[2]Sanjeev Shangary, et al. Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy. Annu Rev Pharmacol Toxicol. 2009;49:223-41.
CAS Number
– 6964-62-1
Molecular Weight
– 340.42
Compound Purity
– 98.12
SMILES
– OC1=C2N=C(C)C=CC2=CC=C1C(C3=CC=CC=C3)NC4=CC=CC=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– MDM-2/p53
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
