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NRX-252262

SKU T9182-1 mL * 10 mM (in DMSO) Category PROTAC Brand: TargetMol

Price range: 186 CAD through 2,288 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– NRX-252262 is a potent enhancer of the interaction between β-Catenin and its cognate E3 ligase, SCFβ-TrCP, inducing mutant β-Catenin degradation (EC50: 3.8 nM).

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T9182

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C23H17Cl2F3N2O4S

References

– Kyle R. Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications. 2019 March.

CAS Number

– 2438637-61-5

Molecular Weight

– C23H17Cl2F3N2O4S

Compound Purity

– 0.9987

SMILES

– COc1cc2CN(Cc2cc1OC)C(=O)c1c(Sc2c(Cl)cccc2Cl)cc([nH]c1=O)C(F)(F)F

Pathway

– Stem Cells|||Cytoskeletal Signaling

Product type

– PROTAC

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.