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Nortriptyline
$77 – $450
Products Details
Product Description
– Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects[1][2][3].
N
Web ID
– HY-118620
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C19H21N
References
– [1]Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. In: Pratt VM, Scott SA, Pirmohamed M, et al., eds. Medical Genetics Summaries. Bethesda (MD): National Center for Biotechnology Information (US); March 23, 2017.|[2]Petrosyan E, et al. Repurposing Autophagy Regulators in Brain Tumors [published online ahead of print, 2022 Feb 18]. Int J Cancer. 2022;10.1002/ijc.33965. |[3]Sheau-Yun Yuan, et al. Nortriptyline induces mitochondria and death receptor-mediated apoptosis in bladder cancer cells and inhibits bladder tumor growth in vivo. Eur J Pharmacol. 2015 Aug 15:761:309-20.
CAS Number
– 72-69-5
Molecular Weight
– 263.38
Compound Purity
– 99.64
SMILES
– CNCC/C=C1C2=CC=CC=C2CCC3=CC=CC=C13
Clinical Information
– Launched
Research Area
– Cancer; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Autophagy;Drug Metabolite
Pathway
– Apoptosis;Autophagy;Metabolic Enzyme/Protease
Product type
– Natural Products
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
