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NLRP3-IN-10
$50 – $400
Products Details
Product Description
– NLRP3-IN-10 is a potent NLRP3 inhibitor, inhibits IL-1β release with an IC50 value of 251.1 nM. NLRP3-IN-10 suppresses NLRP3 inflammasome activation by attenuating ASC speck formation[1].
Web ID
– HY-151343
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C17H14BrFO3
References
– [1]Zhang R, et al. New Highly Potent NLRP3 Inhibitors: Furanochalcone Velutone F Analogues. ACS Med Chem Lett. 2022 Mar 7;13(4):560-569.
CAS Number
– 2641826-39-1
Molecular Weight
– 365.19
Compound Purity
– 98.97
SMILES
– BrC(C=C1OC)=C(C=C1/C=C/C(C2=CC=C(C=C2)F)=O)OC
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– NOD-like Receptor (NLR)
Isoform
– NLRP3
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
