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Neratinib

SKU T2325-5 mg Category Small Compound Brand: TargetMol

Price range: 48 CAD through 525 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T2325

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C30H29ClN6O3

Citations

– 1. Qiu J, Jiang T, Gong Y, et al. Neratinib Exerts Dual Effects on Cartilage Degradation and Osteoclast Production in Osteoarthritis by Inhibiting the Activation of the Mapk/Nf-Κb Signaling Pathways. Biochemical Pharmacology. 2022 Nov;205:115155. 2. Treekitkarnmongkol W, Shah V, Kai K, et al.Epigenetic activation of SOX11 is associated with recurrence and progression of ductal carcinoma in situ to invasive breast cancer.British Journal of Cancer.2024: 1-13.

References

– Canonici A, et al. Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancer. Oncotarget. 2013 Oct;4(10):1592-605.

CAS Number

– 698387-09-6

Molecular Weight

– C30H29ClN6O3

Compound Purity

– 0.9985

SMILES

– N(C=1C2=C(C=C(OCC)C(NC(/C=C/CN(C)C)=O)=C2)N=CC1C#N)C3=CC(Cl)=C(OCC4=CC=CC=N4)C=C3

Pathway

– JAK/STAT signaling|||Angiogenesis|||Tyrosine Kinase/Adaptors

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.