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MK-886

SKU T6893-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 48 CAD through 2,016 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

2 mg 1 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg 500 mg

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Products Details

Product Description

– MK-886 (L 663536) is an inhibitor of leukotriene biosynthesis, acting by inhibiting the 5-lipoxygenase-activating protein (FLAP), and serves as a moderately potent PPARα antagonist.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T6893

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C27H34ClNO2S

Citations

– 1. Wang M, Luo W, Yu T, et al. Corynoline protects ang II-induced hypertensive heart failure by increasing PPARα and Inhibiting NF-κB pathway. Biomedicine & Pharmacotherapy. 2022, 150: 113075 2. Wang, Yuan, et al. Hippocampal PPARα plays a role in the pharmacological mechanism of vortioxetine, a multimodal-acting antidepressant. Frontiers in Pharmacology. 12 (2021). 3. Gao S, Zhang X, Xu H, et al. Promoting the hippocampal PPARα expression participates in the antidepressant mechanism of reboxetine, a selective norepinephrine reuptake inhibitor. Behavioural Brain Research. 2021: 113535. 4. Liang X, Liang J, Zhang S, et al.Di-2-ethylhexyl phthalate disrupts hepatic lipid metabolism in obese mice by activating the LXR/SREBP-1c and PPAR-α signaling pathways.Science of The Total Environment.2024: 169919. 5. Jin L, Zhu W, Hu X, et al.USP25 directly interacts with and deubiquitinates PPARα to increase PPARα stability in hepatocytes and attenuate high-fat diet-induced MASLD in mice.Cell Death & Differentiation.2025: 1-16.

References

– Koeberle A, et al. Eur J Pharmacol. 2009, 608(1-3):84-90.

CAS Number

– 118414-82-7

Molecular Weight

– C27H34ClNO2S

Compound Purity

– 0.9984

SMILES

– CC(C)c1ccc2n(Cc3ccc(Cl)cc3)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c2c1

Pathway

– Neuroscience|||Apoptosis|||Immunology/Inflammation|||DNA Damage/DNA Repair|||Metabolism|||GPCR/G Protein

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.