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Mito-TEMPO

SKU T19428-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 82 CAD through 1,952 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg 500 mg

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Products Details

Product Description

– Mito-TEMPO, a mitochondria-targeted superoxide dismutase mimetic, scavenges superoxide and alkyl radicals, preventing mitochondrial oxidation, necrosis, and apoptosis.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T19428

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C29H35N2O2P.Cl

Citations

– 1. Zhao X, Miao G, Zhang L, et al. Chlamydia pneumoniae Infection Induces Vascular Smooth Muscle Cell Migration and Atherosclerosis Through Mitochondrial Reactive Oxygen Species-Mediated JunB-Fra-1 Activation. Frontiers in Cell and Developmental Biology. 2022, 10: 879023-879023 2. Tian C, Han X, He L, et al. Transient receptor potential ankyrin 1 contributes to the ATP-elicited oxidative stress and inflammation in THP-1-derived macrophage. Molecular and Cellular Biochemistry. 2020: 1-14 3. Wang Y, He X, Xue M, et al.Germacrone protects renal tubular cells against ferroptotic death and ROS release by re-activating mitophagy in diabetic nephropathy.Free Radical Research.2023 (just-accepted): 1-36. 4. Yan Z, Niu L, Wang S, et al.Intestinal Piezo1 aggravates intestinal barrier dysfunction during sepsis by mediating Ca2+ influx.Journal of Translational Medicine.2024, 22(1): 1-12. 5. Tang X, Zheng N, Lin Q, et al.Hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect neurons from cardiac arrest–induced pyroptosis.Neural Regeneration Research.2025: 10.4103. 6. Xu Y, Li G, Ge D, et al.Mitochondrial dysfunction in kidney stones and relief of kidney stones after reducing mtROS.Urolithiasis.2024, 52(1): 117. 7. Liu B, Chen L, Gao M, et al.A Comparative Study of the Efficiency of Mitochondria-Targeted Antioxidants MitoTEMPO and SKQ1 under Oxidative Stress.Free Radical Biology and Medicine.2024 8. XIA L, YUAN H, GAO Z, et al.The role of mitochondrial reactive oxygen species in initiating mitochondrial damage and inflammation in wasp-venom-induced acute kidney injury.Journal of Toxicologic Pathology.2024 9. Xu H, Chen X, Luo S, et al.Cardiomyocyte-specific Piezo1 deficiency mitigates ischemia-reperfusion injury by preserving mitochondrial homeostasis.Redox Biology.2024: 103471.

References

– Mukem S, et al. Mito-Tempo suppresses autophagic flux via the PI3K/Akt/mTOR signaling pathway in neuroblastoma SH-SY5Y cells. Heliyon. 2021 Jun 15;7(6):e07310.

CAS Number

– 1334850-99-5

Molecular Weight

– C29H35N2O2P.Cl

Compound Purity

– 0.9912

SMILES

– [O]N1C(C)(C)CC(NC(C[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)=O)CC1(C)C.[Cl-]

Target

– Others

Pathway

– Metabolism|||NF-κB|||Immunology/Inflammation

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.