MG-132
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MG-132

SKU T2154-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 62 CAD through 795 CAD

Products Details

Product Description

– MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor (IC50=100 nM) that is cell-permeable and reversible. MG-132 acts as an autophagy activator and also induces apoptosis.

Web ID

– T2154

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C26H41N3O5

Citations

– 1. Ding L, Chen X, Zhang W, et al.Canagliflozin primes antitumor immunity by triggering PD-L1 degradation in endocytic recycling.The Journal of Clinical Investigation.2023, 133(1). 2. Zhang W, Pan X, Xu Y, et al.Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA.Acta Pharmaceutica Sinica B.2023 3. Liu X, Fang Y, Lv X, et al.Deubiquitinase OTUD6A in macrophages promotes intestinal inflammation and colitis via deubiquitination of NLRP3.Cell Death & Differentiation.2023: 1-15. 4. Yin L, Ye Y, Zou L, et al.AR antagonists develop drug resistance through TOMM20 autophagic degradation-promoted transformation to neuroendocrine prostate cancer.Journal of Experimental & Clinical Cancer Research.2023, 42(1): 1-19. 5. Zhuge R, Wang C, Wang J, et al.hCINAP regulates the differentiation of embryonic stem cells by regulating NEDD4 liquid-liquid phase-separation-mediated YAP1 activation.Cell Reports.2023, 42(1): 111935. 6. Zhao X, Ma Y, Li J, et al.The AEG-1-USP10-PARP1 axis confers radioresistance in esophageal squamous cell carcinoma via facilitating homologous recombination-dependent DNA damage repair.Cancer Letters.2023: 216440. 7. Cao D, Duan L, Huang B, et al.The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING.Science Signaling.2023, 16(783): eadd0082. 8. Li Y M, Mei Y C, Liu A H, et al.Gcn5-and Bre1-mediated Set2 degradation promotes chronological aging of Saccharomyces cerevisiae.Cell Reports.2023, 42(10). 9. Lin X, Lin T, Wang X, et al.Sesamol serves as a p53 stabilizer to relieve rheumatoid arthritis progression and inhibits the growth of synovial organoids.Phytomedicine.2023: 155109. 10. Zhu X, Huang N, Ji Y, et al.Brusatol induces ferroptosis in oesophageal squamous cell carcinoma by repressing GSH synthesis and increasing the labile iron pool via inhibition of the NRF2 pathway.Biomedicine & Pharmacotherapy.2023, 167: 115567.

References

– Han YH, et al. The effect of MG132, a proteasome inhibitor on HeLa cells in relation to cell growth, reactive oxygen species and GSH. Oncol Rep. 2009 Jul;22(1):215-21.

CAS Number

– 133407-82-6

Molecular Weight

– C26H41N3O5

Compound Purity

– 0.9999

SMILES

– CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=O

Pathway

– Ubiquitination|||Apoptosis|||Autophagy|||Proteases/Proteasome

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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