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Methotrexate

SKU T1485-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 48 CAD through 317 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 g 1 mL * 10 mM (in DMSO)100 mg 25 mg 50 mg 500 mg

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Products Details

Product Description

– Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and various tumors.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T1485

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C20H22N8O5

Citations

– 1. Li X, Xi B, Miao Y, et al. Nintedanib ameliorates imiquimod-induced psoriasis in mice by inhibiting NF-κB and VEGFR2 signaling. International Immunopharmacology. 2021, 100: 108129. 2. Zhao Y, Li Y, Zhu R, et al.RPS15 interacted with IGF2BP1 to promote esophageal squamous cell carcinoma development via recognizing m6A modification.Signal Transduction and Targeted Therapy.2023, 8(1): 224. 3. Kutbi D, Almalki R S.Valsartan Mitigates the Progression of Methotrexate-Induced Acute Kidney Injury in Rats via the Attenuation of Renal Inflammation and Oxidative Stress.Journal of Inflammation Research.2024: 2233-2243. 4. Du J, Zou Q, Shen Y, et al.Monotropein mitigates methotrexate-induced liver injury by activating autophagy and inhibiting ferroptosis.Journal of Functional Foods.2024, 121: 106413. 5. Chen K, Gao Y, Xia N, et al.Long-term therapeutic effects of allogeneic mesenchymal stem cell transplantation for intrauterine adhesions.Stem Cell Research & Therapy.2024, 15(1): 1-13.

References

– Norris RE, et al. Clinical potency of methotrexate, aminopterin, talotrexin and pemetrexed in childhood leukemias. Cancer Chemother Pharmacol. 2010 May;65(6):1125-30.

CAS Number

– 59-05-2

Molecular Weight

– C20H22N8O5

Compound Purity

– 0.9991

SMILES

– NC=1C2=C(N=CC(CN(C)C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)N=C(N)N1

Target

– Others

Pathway

– Antibody-drug Conjugate/ADC Related|||Apoptosis|||Cell Cycle/Checkpoint|||DNA Damage/DNA Repair|||Metabolism

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.