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Lonafarnib

SKU T6302-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 66 CAD through 1,109 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– Lonafarnib (Sch66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM).

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T6302

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C27H31Br2ClN4O2

Citations

– 1. Tangliang Zhao1*, Yi Bao1*,Xinxin Gan1*, Jie Wang1*, Qiong Chen1*, Zhihui Dai2*, Bing Liu 1, Anbang Wang1, Shuhan Sun2, Fu Yang2,3, Linhui Wang1 DNA methylation-regulated QPCT promotes sunitinib resistance by increasing HRAS stability in renal cell carcinoma. Theranostics. 2019, Vol. 9, Issue 21

References

– Liu M, et al. Cancer Res, 1998, 58(21), 4947-4956.

CAS Number

– 193275-84-2

Molecular Weight

– C27H31Br2ClN4O2

Compound Purity

– 0.9994

SMILES

– NC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1

Pathway

– MAPK|||GPCR/G Protein|||Autophagy|||Metabolism

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.