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LDN-57444
Price range: 54 CAD through 778 CAD
Products Details
Product Description
– LDN-57444 is a reversible, competitive inhibitor of the proteasome Uch-L1 with an IC50 of 0.88 μM.
Web ID
– T1924
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C17H11Cl3N2O3
Citations
– 1. Wu W, Xu H, Liao C, et al. Blockade of USP14 potentiates type I interferon signaling and radiation-induced antitumor immunity via preventing IRF3 deubiquitination. Cellular Oncology. 2022: 1-15
2. Yue X, Liu T, Wang X, et al.Pharmacological inhibition of BAP1 recruits HERC2 to competitively dissociate BRCA1–BARD1, suppresses DNA repair and sensitizes CRC to radiotherapy.Acta Pharmaceutica Sinica B.2023
3. Liu S, Chai T, Garcia-Marques F, et al.UCHL1 is a potential molecular indicator and therapeutic target for neuroendocrine carcinomas.Cell Reports Medicine.2024
References
– Liu Y, et al. Chem Biol, 2003, 10(9), 837-846.
CAS Number
– 668467-91-2
Molecular Weight
– C17H11Cl3N2O3
Compound Purity
– 0.9954
SMILES
– CC(=O)ON=C1C(=O)N(Cc2cc(Cl)ccc2Cl)c2ccc(Cl)cc12
Target
– Others
Pathway
– Cell Cycle/Checkpoint|||Apoptosis|||Ubiquitination|||DNA Damage/DNA Repair
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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