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Lapatinib

SKU T0078-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 46 CAD through 206 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 50 mg 500 mg

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Products Details

Product Description

– Lapatinib (GW572016) is an inhibitor of ErbB2 and EGFR (IC50=9.2/10.8 nM) with oral activity. Lapatinib has antitumor activity and can be [research relevance to related conditions] with HER2 overexpression.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T0078

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C29H26ClFN4O4S

Citations

– 1. Pan Z, Wang K, Wang X, et al. Cholesterol promotes EGFR-TKIs resistance in NSCLC by inducing EGFR/Src/Erk/SP1 signaling-mediated ERRα re-expression. Molecular Cancer. 2022, 21(1): 1-17. 2. Kang J, Guo Z, Zhang H, et al. Dual Inhibition of EGFR and IGF-1R Signaling Leads to Enhanced Antitumor Efficacy against Esophageal Squamous Cancer. International Journal of Molecular Sciences. 2022, 23(18): 10382 3. Jiang L, Zeng Y, Ai L, et al. Decreased HMGB1 expression contributed to cutaneous toxicity caused by lapatinib. Biochemical Pharmacology. 2022: 115105 4. Zeng R, Yang X M, Li H W, et al.Simplified Derivatives of Tetrandrine as Potent and Specific P-gp Inhibitors to Reverse Multidrug Resistance in Cancer Chemotherapy.Journal of Medicinal Chemistry.2023 5. Sun R, Ge W, Zhu Y, et al.Proteomic Dynamics of Breast Cancer Cell Lines Identifies Potential Therapeutic Protein Targets.Molecular & Cellular Proteomics.2023: 100602. 6. Yu T, Zeng R, Guan Y, et al.Discovery of new tricyclic spiroindole derivatives as potent P-glycoprotein inhibitors for reversing multidrug resistance enabled by synthetic methodology-based library.RSC Medicinal Chemistry.2024 7. Abdelaal N, Ragheb M A, Hassaneen H M, et al.Design, in silico studies and biological evaluation of novel chalcones tethered triazolo [3, 4-a] isoquinoline as EGFR inhibitors targeting resistance in non-small cell lung cancer.Scientific Reports.2024, 14(1): 26647.

References

– Wainberg ZA, et al. Lapatinib, a dual EGFR and HER2 kinase inhibitor, selectively inhibits HER2-amplified human gastric cancer cells and is synergistic with trastuzumab in vitro and in vivo. Clin Cancer Res. 2010 Mar 1;16(5):1509-19.

CAS Number

– 231277-92-2

Molecular Weight

– C29H26ClFN4O4S

Compound Purity

– 0.9989

SMILES

– N(C=1C2=C(C=CC(=C2)C=3OC(CNCCS(C)(=O)=O)=CC3)N=CN1)C4=CC(Cl)=C(OCC5=CC(F)=CC=C5)C=C4

Target

– Autophagy|||Topoisomerase

Pathway

– Angiogenesis|||Autophagy|||Apoptosis|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.