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KRIBB11
SKU
HY-100872-10 mg
Category Reference compound
Tags Apoptosis;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease, Apoptosis;HSP, Cancer
$60 – $648
Products Details
Product Description
– KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC50 of 1.2 μM.
Web ID
– HY-100872
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C13H12N6O2
References
– [1]Yoon YJ, et al. KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter. J Biol Chem. 2011 Jan 21;286(3):1737-47|[2]Samarasinghe B, et al. Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux. Biochem Pharmacol. 2014 Feb 1;87(3):445-55
CAS Number
– 342639-96-7
Molecular Weight
– 284.27
Compound Purity
– 99.12
SMILES
– CNC1=CC=C([N+]([O-])=O)C(NC2=CC3=C(NN=C3)C=C2)=N1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 150 mg/mL (ultrasonic)
Target
– Apoptosis;HSP
Isoform
– HSF1
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Product type
– Reference compound
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