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Kobophenol A
$300 – $630
Products Details
Product Description
– Kobophenol A, an oligomeric stilbene, blocks the interaction between the ACE2 receptor and S1-RBD with an IC50 of 1.81 μM and inhibits SARS-CoV-2 viral infection in cells with an EC50 of 71.6 μM. Kobophenol A inhibits the activity of partially purified rat brain protein kinase C (PKC) with an IC50 of 52 µM[1][2].
Web ID
– HY-126419
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C56H44O13
References
– [1]Gangadevi S, et al. Kobophenol A Inhibits Binding of Host ACE2 Receptor with Spike RBD Domain of SARS-CoV-2, a Lead Compound for Blocking COVID-19. J Phys Chem Lett. 2021;12(7):1793-1802.|[2]Xu G, Zhang LP, Chen LF, Hu CQ. Yao Xue Xue Bao. 1994;29(11):818-822.
CAS Number
– 124027-58-3
Molecular Weight
– 924.94
Compound Purity
– 99.90
SMILES
– OC1=CC([C@H]([C@@H](C(C=C2)=CC=C2O)OC3=C4)C3=C([C@@H]5[C@H](C6=CC(O)=CC(O)=C6)[C@@H](C(C=C7)=CC=C7O)O[C@@H]5C(C=C8)=CC=C8O)C=C4O)=C9[C@@H](C%10=CC(O)=CC(O)=C%10)[C@H](C(C=C%11)=CC=C%11O)OC9=C1
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– PKC;SARS-CoV
Pathway
– Anti-infection;Epigenetics;TGF-beta/Smad
Product type
– Natural Products
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
