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Ketanserin
$55 – $77
Products Details
Product Description
– Ketanserin is a selective 5-HT2 receptor antagonist. Ketanserin also blocks hERG current (IhERG) in a concentration-dependent manner (IC50=0.11 μM).
Web ID
– HY-10562
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C22H22FN3O3
References
– [1]Tang Q, et al. The 5-HT2 antagonist Ketanserin is an open channel blocker of human cardiac ether-Ã -go-go-related gene (hERG) potassium channels. Br J Pharmacol. 2008 Oct;155(3):365-73.|[2]Khan N, et al. Investigation of cyclooxygenase and signaling pathways involved in human platelet aggregation mediated by synergistic interaction of various agonists. Drug Des Devel Ther. 2015 Jul 6;9:3497-506.|[3]Kekewska A, et al. Antiserotonergic properties of terguride in blood vessels, platelets, and valvular interstitial cells. J Pharmacol Exp Ther. 2012 Feb;340(2):369-76.|[4]Jiang DG, et al. Serotonin regulates brain-derived neurotrophic factor expression in select brain regions during acute psychological stress. Neural Regen Res. 2016 Sep;11(9):1471-1479.
CAS Number
– 74050-98-9
Molecular Weight
– 395.43
Compound Purity
– 99.24
SMILES
– O=C(C1=CC=CC=C1N2)N(CCN3CCC(C(C4=CC=C(F)C=C4)=O)CC3)C2=O
Clinical Information
– Launched
Research Area
– Neurological Disease
Solubility
– DMF : 5 mg/mL (ultrasonic)|DMSO : 16.67 mg/mL (ultrasonic)
Target
– 5-HT Receptor;Autophagy;Potassium Channel
Isoform
– 5-HT2 Receptor
Pathway
– Autophagy;GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
