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JR-AB2-011

SKU T11728-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 139 CAD through 2,128 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– JR-AB2-011 is a selective mTORC2 inhibitor with an IC50 value of 0.36 μM. It inhibits mTORC2 activity by blocking Rictor-mTOR association (Ki: 0.19 μM) and exhibits cytotoxicity in glioblastoma [1].

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T11728

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C17H14Cl2FN3OS

Citations

– 1. Xu W, Qadir M M F, Nasteska D, et al.Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells.Cell Reports.2023, 42(5). 2. Zhou S, Lin W, Jin X, et al.CD97 maintains tumorigenicity of glioblastoma stem cells via mTORC2 signaling and is targeted by CAR Th9 cells.Cell Reports Medicine.2024

References

– Benavides-Serrato A, et al. Correction: Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxicin glioblastoma. PLoS One. 2019 Feb 6;14(2):e0212160.

CAS Number

– 2411853-34-2

Molecular Weight

– C17H14Cl2FN3OS

Compound Purity

– 0.9887

SMILES

– CC1CN(C(=O)Nc2ccc(Cl)c(Cl)c2)C(S1)=Nc1ccc(F)cc1

Target

– Others

Pathway

– PI3K/Akt/mTOR signaling

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.