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JH-RE-06

SKU T15611-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 62 CAD through 1,856 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing the recruitment of mutagenic POLζ. JH-RE-06 is an effective REV1-REV7 interface inhibitor (IC50=0.78 μM; Kd=0.42 μM), which targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 also improves chemotherapy.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T15611

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C20H16Cl3N3O4

Citations

– 1. Chen Y, Jie X, Xing B, et al. REV1 promotes lung tumorigenesis by activating the Rad18/SERTAD2 axis. Cell Death & Disease. 2022, 13(2): 1-11. 2. Chen Y, Jie X, Xing B, et al. REV1 promotes lung tumorigenesis by activating the Rad18/SERTAD2 axis. Cell Death & Disease. 2022, 13(2): 1-11. 3. Chen Y, Feng X, Wu Z, et al.USP9X-mediated REV1 deubiquitination promotes lung cancer radioresistance via the action of REV1 as a Rad18 molecular scaffold for cystathionine γ-lyase.Journal of Biomedical Science.2024, 31(1): 55.

References

– Wojtaszek JL, et al. A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy. Cell. 2019 Jun 27;178(1):152-159.e11.

CAS Number

– 1361227-90-8

Molecular Weight

– C20H16Cl3N3O4

Compound Purity

– 0.9929

SMILES

– CC(C)CC(=O)c1c(Nc2ccc(Cl)cc2Cl)[nH]c2c(Cl)ccc([N+]([O-])=O)c2c1=O

Target

– Others

Pathway

– DNA Damage/DNA Repair|||Cell Cycle/Checkpoint

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.