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JAK2-IN-6

SKU T40443-1 mg Category Small Compound Brand: TargetMol

Price range: 51 CAD through 1,038 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– JAK2-IN-6, a polysubstituted aminothiazole derivative, is a potent and selective inhibitor of JAK2 (ic50 at 22.86 μg/mL). Jak2-in-6 inhibits the activity of JAK2 enzymes by interfering with Jak2-related signaling pathways, thereby producing therapeutic effects on the specific disease IN which JAK2 is dysregulated, and does not show activity on JAK1 and JAK3. JAK2 is a protein involved in signaling pathways that regulate cell growth and division. Abnormal activation of JAK2 has been linked to a variety of diseases, including some types of cancer and inflammatory diseases. JAK2-IN-6 has antiproliferative activity against cancer cells.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T40443

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C14H10ClN3OS2

References

– Yao T T, et al. Integration of pharmacophore mapping and molecular docking in sequential virtual screening: towards the discovery of novel JAK2 inhibitors. RSC advances, 2017, 7(17): 10353-10360.

CAS Number

– 353512-04-6

Molecular Weight

– C14H10ClN3OS2

Compound Purity

– 0.98

SMILES

– Nc1nc(Nc2ccccc2)sc1C(=O)c1ccc(Cl)s1

Pathway

– Angiogenesis|||Chromatin/Epigenetic|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors|||Stem Cells

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.