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Products Details
Product Description
– ICy-Q is a quinone oxidoreductase 1 (NQO-1)-activated near-infrared (NIR) reagent which can react with NQO-1 to release the reduction product ICy-OH. ICy-OH selectively induces pancreatic cancer cell death through the pyroptosis pathway. ICy-Q can be used as an effective tool for rapid and accurate diagnosis of intraoperative pathological sections[1].
Web ID
– HY-150971
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C48H50I2N2O5
References
– [1]Bo Peng, et al. NQO-1 Enzyme-Activated NIR Theranostic Agent for Pancreatic Cancer. Anal Chem. 2022 Aug 2.
CAS Number
– 2863682-83-9
Molecular Weight
– 988.73
SMILES
– CC1=C(C(C(C(C)(C)CC(N(C2=CC=C(C=C2)COC3=CC4=C(C=C5CCCC(/C=C/C6=[N+](C7=C(C6(C)C)C=C(C=C7)I)C)=C5O4)C=C3)C)=O)=C(C1=O)C)=O)C.[I-]
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Pyroptosis
Pathway
– Apoptosis;Immunology/Inflammation
Product type
– Reference compound
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