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ICCB-19 hydrochloride

SKU T8931L-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 48 CAD through 834 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 5 mg 50 mg 500 mg

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Products Details

Product Description

– ICCB-19 hydrochloride (ICCB-19 HCl) is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N), which interacts with the C-terminal domain (TRADD-C) and TRAF2 to modulate the ubiquitination of RIPK1 and beclin 1.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T8931L

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C12H22ClN3OS

Citations

– 1. Zheng M, Zhai Y, Yu Y, et al.TNF compromises intestinal bile-acid tolerance dictating colitis progression and limited infliximab response.Cell Metabolism.2024

References

– Xu D , Zhao H , Jin M , et al. Modulating TRADD to restore cellular homeostasis and inhibit apoptosis[J]. Nature, 2020, 587(7832):1-6.

CAS Number

– 1803605-68-6

Molecular Weight

– C12H22ClN3OS

Compound Purity

– 0.993

SMILES

– Cl.O=C(CSC1=NCCN1)NC1CCCCCC1

Pathway

– Autophagy|||NF-κB|||Apoptosis

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.