Download Files:
HODHBt
Size – 100 mg
$50
Only 1000 item(s) left in stock.
Products Details
Product Description
– HODHBt (HOOBt) inhibits STAT5-SUMO interaction by blocking SUMOylation of phosphorylated STAT5. HODHBt enhances the magnitude of IL-15 signaling and significantly increases the natural killer (NK) cell cytotoxicity phenotype and function and the generation of cytokine-induced memory-like (CIML) natural killer (NK) cells. HODHBt can be used for research of HIV-infection and cancer[1].
Web ID
– HY-Y0493
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Molecular Formula
– C7H5N3O2
References
– [1]Macedo AB, et al. The HIV Latency Reversal Agent HODHBt Enhances NK Cell Effector and Memory-Like Functions by Increasing Interleukin-15-Mediated STAT Activation. J Virol. 2022 Aug 10;96(15):e0037222.
CAS Number
– 28230-32-2
Molecular Weight
– 163.13
Compound Purity
– 99.97
SMILES
– O=C1N(O)N=NC2=CC=CC=C12
Clinical Information
– No Development Reported
Research Area
– Cancer, Infection
Solubility
– DMSO : 500 mg/mL (ultrasonic)
Target
– HIV, STAT
Isoform
– STAT5
Pathway
– Anti-infection, JAK/STAT Signaling, Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
