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Products Details
Product Description
– HIV-1 inhibitor-49 is an orally active HIV-1 inhibitor, is a HEPT analog. HIV-1 inhibitor-49 possesses great pharmacokinetics profiles and potent non-nucleoside reverse transcriptase inhibitory activity (IC50=30 nM). HIV-1 inhibitor-49 exerts potential safety without acute toxicity in mouse model[1].
Web ID
– HY-151933
Shipping
– Room temperature
Molecular Formula
– C21H18F2N2O3S
References
– [1]Zhou RL, et al. Structure-guided design of novel HEPT analogs with enhanced potency and safety: From Isopropyl-HEPTs to Cyclopropyl-HEPTs. Eur J Med Chem. 2022 Nov 24;246:114939.
Molecular Weight
– 416.44
SMILES
– O=C1NC(N(C(SC2=CC(F)=CC=C2F)=C1C3CC3)COCC4=CC=CC=C4)=O
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– HIV;Reverse Transcriptase
Isoform
– HIV-1
Pathway
– Anti-infection
Product type
– Reference compound
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