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HC-067047

SKU T4680-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 48 CAD through 845 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– HC-067047 is a potent and selective TRPV4 antagonist that also inhibits the endogenous TRPV4-mediated response to 4α-PDH.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T4680

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C26H28F3N3O2

Citations

– 1. Li W, Xu Y, Liu Z, et al. TRPV4 inhibitor HC067047 produces antidepressant-like effect in LPS-induced depression mouse model. Neuropharmacology. 2021: 108834. 2. Dongming G, Xu Y, Wang Y, et al. Hyperactivation of TRPV4 causes the hippocampal pyroptosis pathway and results in cognitive impairment in LPS-treated mice. Behavioural Brain Research. 2022: 114223. 3. Deng Y, Li W, Niu L, et al. Amelioration of scopolamine-induced learning and memory impairment by the TRPV4 inhibitor HC067047 in ICR mice. Neuroscience Letters. 2022, 767: 136209. 4. Chen L, Mao M, Liu D, et al.HC067047 as a potent TRPV4 inhibitor repairs endotoxemia colonic injury.International Immunopharmacology.2023, 116: 109648. 5. Zhong X, Wang Y, Liu D, et al.HC067047 Ameliorates SAE by Suppressing Endoplasmic Reticulum Stress and Oxidative Stress-Induced Pyroptosis in the Hippocampi of Mice.Neuroscience.2023 6. Kong S, Chen T, Jia X, et al.Cell-specific NFIA upregulation promotes epileptogenesis by TRPV4-mediated astrocyte reactivity.Journal of Neuroinflammation.2023, 20(1): 1-22.

References

– Everaerts W et al. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis.Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19084-9.

CAS Number

– 883031-03-6

Molecular Weight

– C26H28F3N3O2

Compound Purity

– 0.9997

SMILES

– Cc1c(cc(-c2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F

Pathway

– Membrane transporter/Ion channel

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.