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Halofuginone hydrobromide

SKU T3524-1 mL * 10 mM (in DMSO) Category Natural Product Brand: TargetMol

Price range: 50 CAD through 1,594 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

2 mg 1 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg 500 mg

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Products Details

Product Description

– Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibroproliferative diseases.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T3524

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C16H17BrClN3O3.HBr

Citations

– 1. Kaduk J A, Gates-Rector S, Blanton T N. Crystal structure of halofuginone hydrobromide, C16H18BrClN3O3Br. Powder Diffraction. 2022: 1-8. 2. Zhu J, Wei J, Lin Y, et al.Inhibition of IL-17 signaling in macrophages underlies the anti-arthritic effects of halofuginone hydrobromide: Network pharmacology, molecular docking, and experimental validation.BMC Complementary Medicine and Therapies.2024, 24(1): 1-12.

References

– Zhou H. et al. ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase. Nature. 2013 Feb 7;494(7435):121-4.

CAS Number

– 64924-67-0

Molecular Weight

– C16H17BrClN3O3.HBr

Compound Purity

– 0.985

SMILES

– Br.O[C@H]1CCCN[C@@H]1CC(=O)Cn1cnc2cc(Br)c(Cl)cc2c1=O

Target

– Others

Pathway

– Metabolism|||Cell Cycle/Checkpoint|||DNA Damage/DNA Repair|||Membrane transporter/Ion channel|||Microbiology/Virology|||Stem Cells

Product type

– Natural Product

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.