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GW9662

SKU T2260-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 75 CAD through 869 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg 500 mg

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Products Details

Product Description

– GW9662 (TIMTEC-BB SBB006523) is a specific PPARγ antagonist (IC50: 3.3 nM, in a cell-free assay), with 100 to 1000-fold functional selectivity for PPARγ than PPARα/δ in cells.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T2260

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C13H9ClN2O3

Citations

– 1. Miao Y, Wu X, Xue X, et al. Morin, the PPARγ agonist, inhibits Th17 differentiation by limiting fatty acid synthesis in collagen-induced arthritis. Cell Biology and Toxicology. 2022: 1-20. 2. Yang L, Zheng Y, Miao Y, et al. Bergenin, a PPARγ agonist, inhibits Th17 differentiation and subsequent neutrophilic asthma by preventing GLS1-dependent glutaminolysis. Acta Pharmacologica Sinica. 2021: 1-14. 3. Miao Y, Zhang C, Yang L, et al. The activation of PPARγ enhances Treg responses through up-regulating CD36/CPT1-mediated fatty acid oxidation and subsequent N-glycan branching of TβRII/IL-2Rα. Cell Communication and Signaling. 2022, 20(1): 1-22 4. Miao Y, Zhang Y, Qiao S, et al. Oral administration of curcumin ameliorates pulmonary fibrosis in mice through 15d-PGJ2-mediated induction of hepatocyte growth factor in the colon. Acta Pharmacologica Sinica. 2020: 1-14 5. Zong X, Wang H, Xiao X, et al. Cathelicidin-WA facilitated intestinal fatty acid absorption through enhancing PPAR-γ dependent barrier function. Frontiers in immunology. 2019, 10: 1674. 6. Qiao N, Lin Y, Wang Z, et al. Maresin1 Promotes M2 Macrophage Polarization Through peroxisome proliferator–activated receptor-γ Activation to Expedite Resolution of Acute Lung Injury. Journal of Surgical Research. 2020, 256: 584-594. 7. Lin X, Ma Y, Qian T, et al. Basic Fibroblast Growth Factor Promotes Prehierarchical Follicle Growth and Yolk Deposition in the Chicken. Theriogenology. 2019 8. Xie X, Zhang W, Zhou X, et al.Low doses of IFN-γ maintain self-renewal of leukemia stem cells in acute myeloid leukemia.Oncogene.2023: 1-13.

References

– Leesnitzer LM, et al. Biochemistry, 2002, 41(21), 6640-6650.

CAS Number

– 22978-25-2

Molecular Weight

– C13H9ClN2O3

Compound Purity

– 0.9994

SMILES

– [O-][N+](=O)c1ccc(Cl)c(c1)C(=O)Nc1ccccc1

Pathway

– Metabolism|||DNA Damage/DNA Repair

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.