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GW4869

SKU T3640-1 mg Category Small Compound Brand: TargetMol

Price range: 80 CAD through 1,496 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– GW4869 (GW69A) is a selective and non-competitive inhibitor of neutral sphingomyelinase N-SMase (IC50=1 μM). GW4869 also inhibits exosome synthesis/release and is commonly used in exosome-related studies.Usually prepared as a suspension for experiments.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T3640

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C30H30Cl2N6O2

Citations

– 1. Han X, de Dieu Habimana J, Li A L, et al. Transcription factor EB-mediated mesenchymal stem cell therapy induces autophagy and alleviates spinocerebellar ataxia type 3 defects in neuronal cells model. Cell death & disease. 2022, 13(7): 1-12. 2. Ge M, Qiao Z, Kong Y, et al. Exosomes mediate intercellular transfer of non-autonomous tolerance to proteasome inhibitors in mixed-lineage leukemia. Cancer Science. 2020 3. Wang X, Chen Q Z, Zan Y X, et al. Exosomal miR‐145‐5p derived from orthohantavirus‐infected endothelial cells inhibits HTNV infection. The FASEB Journal. 2020, 34(10): 13809-13825. 4. Shi F, Deng Z, Zhou Z, et al. Heat injured stromal cells‐derived exosomal EGFR enhances prostatic wound healing after thulium laser resection through EMT and NF‐κB signaling. The Prostate. 2019 May 24 5. Han C, Xia X, Jiao S, et al. Tripartite motif containing protein 37 involves in thrombin stimulated BV-2 microglial cell apoptosis and interleukin 1β release. Biochemical and biophysical research communications. 2019, 516(4): 1252-1257. 6. Cao Z, Li P, Li Y, et al.Encapsulation of Nano‐Bortezomib in Apoptotic Stem Cell‐Derived Vesicles for the Treatment of Multiple Myeloma.Small.2023: 2301748. 7. Wang W, Sun J C, Ye P, et al.miR‐22‐3p in the rostral ventrolateral medulla promotes hypertension through inhibiting β‐arrestin‐1.The Journal of Physiology.2023 8. Xu H, Li X, Liu K, et al.PM2. 5 Promotes Macrophage-Mediated Inflammatory Response Through Airway Epithelial Cell-Derived Exosomal miR-155-5p.Journal of Inflammation Research.2024: 8555-8567.

References

– Luberto C, et al. Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase. J Biol Chem. 2002 Oct 25;277(43):41128-39.

CAS Number

– 6823-69-4

Molecular Weight

– C30H30Cl2N6O2

Compound Purity

– 0.9966

SMILES

– Cl.Cl.O=C(Nc1ccc(cc1)C1=NCCN1)C=Cc1ccc(C=CC(=O)Nc2ccc(cc2)C2=NCCN2)cc1

Pathway

– Metabolism

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.