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Fulvestrant
Price range: 67 CAD through 189 CAD
Products Details
Product Description
– Fulvestrant (ZM 182780) is an estrogen receptor (ER) antagonist (IC50=9.4 nM) and an agonist of GPR30. Fulvestrant has antitumor activity, inhibiting cell proliferation and inducing apoptosis and autophagy.
Web ID
– T2146
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C32H47F5O3S
Citations
– 1. Yang R, Wang X, Wang J, et al. Insights into the sex-dependent reproductive toxicity of 2-ethylhexyl diphenyl phosphate on zebrafish (Danio rerio). Environment International. 2022, 158: 106928.
2. Zhao Z, Xue F, Gu Y, et al. Crosstalk between the muscular estrogen receptor α and BDNF/TrkB signaling alleviates metabolic syndrome via 7, 8-dihydroxyflavone in female mice. Molecular Metabolism. 2020: 101149.
3. Chen D, Tan Y, Li Z, et al. Organoid cultures derived from patients with papillary thyroid cancer. The Journal of Clinical Endocrinology & Metabolism. 2021 Apr 23;106(5):1410-1426. doi: 10.1210/clinem/dgab020.
4. Wang, Zixiang, et al. EVI1 overexpression promotes ovarian cancer progression by regulating estrogen signaling. Molecular and Cellular Endocrinology. (2021): 111367.
5. Xiao Y, Chen D. ERα, but not ERβ and GPER, Mediates Estradiol‑Induced Secretion of TSH in Mouse Pituitary. Applied Biochemistry and Biotechnology. 2022: 1-11
6. Huang C S, Deng H F, Zhou L, et al.Undesirable ER stress induced by bavachin contributed to follicular atresia in zebrafish ovary.Biomedicine & Pharmacotherapy.2023, 166: 115322.
7. Cui S, Suo N, Yang Y, et al.The aminosteroid U73122 promotes oligodendrocytes generation and myelin formation.Acta Pharmacologica Sinica.2023: 1-12.
8. Peng B, Ran T, Chen X, et al.A CARM1 Inhibitor Potently Suppresses Breast Cancer Both In Vitro and In Vivo.Journal of Medicinal Chemistry.2024
9. Yan X, Luo C, Yang J, et al.Antiviral Activity of Selective Estrogen Receptor Modulators against Severe Fever with Thrombocytopenia Syndrome Virus In Vitro and In Vivo.Viruses.2024, 16(8): 1332.
10. Zhang X, Yuan X, Li X, et al.Sodium Danshensu Alleviates Bone Cancer Pain by Inhibiting the Osteoclast Differentiation and CGRP Expression.European Journal of Pharmacology.2025: 177296.
References
– Nukatsuka M, et al. Estrogen Down-regulator Fulvestrant Potentiates Antitumor Activity of Fluoropyrimidine in Estrogen-responsive MCF-7 Human Breast Cancer Cells. In Vivo. 2019 Sep-Oct;33(5):1439-1445.
CAS Number
– 129453-61-8
Molecular Weight
– C32H47F5O3S
Compound Purity
– 0.997
SMILES
– [H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])c3ccc(O)cc3C[C@@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)[C@@]21[H]
Pathway
– Autophagy|||Apoptosis|||Endocrinology/Hormones
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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