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Fluvastatin (sodium)
$79 – $119
Products Details
Product Description
– Fluvastatin sodium (XU 62320) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin sodium protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1][2][3].
Web ID
– HY-14664A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C24H25FNNaO4
Citations
– Front Bioeng Biotechnol. 2022 Mar 17;10:826093.|Mol Med Rep. 2018 Mar;17(3):3944-3950.|Pathogens. 2021, 10(3), 283.|Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868.|Cell Prolif. 2021 Jan;54(1):e12953.|Chem Eng J. 1 January 2023, 138972.|Front Cell Dev Biol. 2020 May 28;8:404.|Front Oncol. 10 May 2021.|Front Oncol. 2021 May 10;11:595285.|Pharmacol Res. 2023 Mar 10;106724.|Proteomics. 2023 May 4;e2300041.
References
– [1]Makabe S, et al. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. Atherosclerosis. 2010 Dec;213(2):377-84.|[2]Wu Zhang, et al. Fluvastatin, a lipophilic statin, induces apoptosis in human hepatocellular carcinoma cells through mitochondria-operated pathway. Indian J Exp Biol. 2010 Dec;48(12):1167-74.
CAS Number
– 93957-55-2
Molecular Weight
– 433.45
Compound Purity
– 99.90
SMILES
– O=C(O[Na])C[C@H](O)C[C@H](O)/C=C/C(N1C(C)C)=C(C2=CC=C(F)C=C2)C3=C1C=CC=C3
Clinical Information
– Launched
Research Area
– Cardiovascular Disease; Cancer
Solubility
– DMSO : 50 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
Target
– Autophagy;Ferroptosis;HMG-CoA Reductase (HMGCR)
Pathway
– Apoptosis;Autophagy;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
