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Fluralaner

SKU T5330-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 46 CAD through 94 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 25 mg

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Products Details

Product Description

– Fluralaner (A1443) is an isoxazoline ectoparasiticide. It potently and selectively inhibits binding of the GABA receptor channel blocker EBOB to housefly head membranes (IC50: 455 pM).

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T5330

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C22H17Cl2F6N3O3

Citations

– 1. Gastaldi M S, Felsztyna I, Miguel V, et al.Theoretical and Experimental Study of Molecular Interactions of Fluralaner with Lipid Membranes.Journal of Agricultural and Food Chemistry.2023 2. Li B J, Wang K K, Yu Y, et al.PxRdl2 dsRNA increased the insecticidal activities of GABAR-targeting compounds against Plutella xylostella.Pesticide Biochemistry and Physiology.2023: 105548. 3. Rodriguez M A, Felsztyna I, García D A, et al.Interaction of fluralaner with binary model membranes. Potential implications in the selectivity for invertebrates/vertebrates.Journal of Molecular Liquids.2024: 124891.

References

– Ozoe Y, et al. The antiparasitic isoxazoline A1443 is a potent blocker of insect ligand-gated chloride channels. Biochem Biophys Res Commun. 2010 Jan 1;391(1):744-9.

CAS Number

– 864731-61-3

Molecular Weight

– C22H17Cl2F6N3O3

Compound Purity

– 0.9977

SMILES

– Cc1cc(ccc1C(=O)NCC(=O)NCC(F)(F)F)C1=NOC(C1)(c1cc(Cl)cc(Cl)c1)C(F)(F)F

Pathway

– Neuroscience|||Membrane transporter/Ion channel|||Microbiology/Virology

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.