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Ethacrynic acid

SKU T4564-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 50 CAD through 237 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)100 mg 25 mg 50 mg 500 mg

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Products Details

Product Description

– Ethacrynic acid (Edecrin) is a nonsulfonamide loop diuretic that inhibits the activity of the Na+/K+/2Cl- cotransporter NKCC2 in the thick ascending limb of the loop of Henle. It also inhibits glutathione S-transferase and Wnt signalling, producing cytotoxicity in chronic lymphocytic leukaemia cells and other tumour cells.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T4564

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C13H12Cl2O4

Citations

– 1. Tang Y, Song H, Wang Z, et al. Repurposing antiparasitic antimonials to noncovalently rescue temperature-sensitive p53 mutations. Cell Reports. 2022, 39(2): 110622 2. Tang Y, Song H, Wang Z, et al.Repurposing antiparasitic antimonials to noncovalently rescue temperature-sensitive p53 mutations.Cell Reports.2022, 39(2): 110622.

References

– Kunugi Y, et al. Ethacrynic acid-sensitive and ATP-dependent Cl- transport in the rat kidney[J]. Japanese Journal of Pharmacology, 1991, 57(2):167-74.

CAS Number

– 58-54-8

Molecular Weight

– C13H12Cl2O4

Compound Purity

– 0.9915

SMILES

– CCC(=C)C(=O)C1=CC=C(OCC(O)=O)C(Cl)=C1Cl

Pathway

– NF-κB|||Membrane transporter/Ion channel|||Oxidation-Reduction|||Metabolism

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.