Download Files:
Estradiol
Price range: 48 CAD through 312 CAD
Products Details
Product Description
– Estradiol (E2) is a naturally occurring steroidal sex hormone that is essential for female fertility and maintenance of secondary sexual characteristics. Estradiol upregulates IL-6 expression through estrogen receptor beta (ERβ).
Web ID
– T1048
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C18H24O2
Citations
– 1. Lu Z, Cao Y, Zhang D, et al. Discovery of Thieno [2, 3-e] indazole Derivatives as Novel Oral Selective Estrogen Receptor Degraders with Highly Improved Antitumor Effect and Favorable Druggability. Journal of Medicinal Chemistry. 2022
2. Qiao L, Wang H, He J, et al. Truncated affinity-improved aptamers for 17β-estradiol determination by AuNPs-based colorimetric aptasensor. Food Chemistry. 2020: 128181
3. Zhang S, Sun C, Zhao S, et al. Exposure to DEHP or its metabolite MEHP promotes progesterone secretion and inhibits proliferation in mouse placenta or JEG-3 cells. Environmental Pollution. 2020, 257: 113593
4. Liu A, Jin M, Xie L, et al. Loss of miR-29a impairs decidualization of endometrial stromal cells by TET3 mediated demethylation of Col1A1 promoter. Iscience. 2021, 24(9): 103065.
5. Wang Y, Xu G, Wang Z, et al. Psoralidin, a major component of Psoraleae Fructus, induces inflammasome activation and idiosyncratic liver injury. International Immunopharmacology. 2021 Mar;92:107352. doi: 10.1016/j.intimp.2020.107352. Epub 2021 Jan 7.
6. Cui L, Xu F, Jiang Z, et al. Melatonin regulates proliferation and apoptosis of endometrial stromal cells via MT1. Acta Biochimica et Biophysica Sinica. 2021
7. Cui L, Xu F, Xu C, et al.Circadian gene Rev-erbα influenced by sleep conduces to pregnancy by promoting endometrial decidualization via IL-6-PR-C/EBPβ axis.Journal of Biomedical Science.2022, 29(1): 1-14.
8. Zhang D, Ma B, Liu D, et al.Discovery of a peptide proteolysis-targeting chimera (PROTAC) drug of p300 for prostate cancer therapy.EBioMedicine.2024, 105.
9. Zhang D, Lu Z, He Y, et al.Discovery of Thiochroman Derivatives as Potent, Oral Selective Estrogen Receptor Degraders and Antagonists for the Treatment of Endocrine-Resistant Breast Cancer.Journal of Medicinal Chemistry.2024
10. Xiao Y, Tao M, He J, et al.TIG1 Triggers Placental Senescence in Preeclampsia through LMNA/p53 Axis Activation.Placenta.2024
References
– Celojevic D, et al. Effects of 17β-estradiol on proliferation, cell viability and intracellular redox status in native human lens epithelial cells. Mol Vis. 2011;17:1987-96. Epub 2011 Jul 20.
CAS Number
– 50-28-2
Molecular Weight
– C18H24O2
Compound Purity
– 0.998
SMILES
– CC12CCC3C(CCc4cc(O)ccc34)C1CCC2O
Target
– Others
Pathway
– Endocrinology/Hormones|||Metabolism
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
Related Products
1000 in stock
