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Entrectinib

SKU T3678-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 56 CAD through 1,165 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

2 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg 500 mg

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Products Details

Product Description

– Entrectinib (RXDX-101) is a Trk, ROS1, and ALK inhibitor that inhibits TrkA, TrkB, TrkC, ROS1, and ALK (IC50=1/3/5/12/7 nM) with oral activity and blood-brain-barrier penetration. Entrectinib exhibits both antitumor and CNS activity.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T3678

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C31H34F2N6O2

Citations

– 1. Shi S, Ma B, Sun F, et al. Zafirlukast inhibits the growth of lung adenocarcinoma via inhibiting TMEM16A channel activity. Journal of Biological Chemistry. 2022, 298(3). 2. Qin Q, Fu Q, Wang X, et al.Design, synthesis and biological evaluation of novel indolin-2-one derivatives as potent second-generation TRKs inhibitors.European Journal of Medicinal Chemistry.2023: 115291. 3. Jin X, Liu D, Zhou X, et al.Entrectinib inhibits NLRP3 inflammasome and inflammatory diseases by directly targeting NEK7.Cell Reports Medicine.2023, 4(12). 4. Ding X, Li X, Fang R, et al.Targeting PYK2, entrectinib allays anterior subcapsular cataracts in mice by regulating TGFβ2 signaling pathway.Molecular Medicine.2024, 30(1): 1-15.

References

– Rolfo C, et al. Expert Opin Investig Drugs. 2015, 24(11), 1493-1500.

CAS Number

– 1108743-60-7

Molecular Weight

– C31H34F2N6O2

Compound Purity

– 0.9961

SMILES

– N(C(=O)C1=C(NC2CCOCC2)C=C(C=C1)N3CCN(C)CC3)C=4C=5C(NN4)=CC=C(CC6=CC(F)=CC(F)=C6)C5

Pathway

– Immunology/Inflammation|||Angiogenesis|||Autophagy|||Tyrosine Kinase/Adaptors

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.