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Elenbecestat
$190 – $1,700
Products Details
Product Description
– Elenbecestat (E2609) is a potent, orally bioavailable and CNS-penetrant BACE-1 inhibitor. Elenbecestat has the potential for Alzheimer’s disease (AD) research[1][2].
Web ID
– HY-109055
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C19H18F3N5O2S
References
– [1]Kumar D, et al.Secretase inhibitors for the treatment of Alzheimer’s disease: Long road ahead. Eur J Med Chem. 2018 Mar 25;148:436-452.|[2]A single dose of the beta-secretase inhibitor, e2609, decreases CSF bace1 enzymatic activity in cynomolgus monkeys. Alzheimer’s & Dementia, 8(4), P224.
CAS Number
– 1388651-30-6
Molecular Weight
– 437.44
Compound Purity
– 99.94
SMILES
– FC1=CC=C(NC(C2=NC=C(C(F)F)N=C2)=O)C=C1[C@@]3(N=C(N)SC4)[C@@]4([H])[C@@H](C)OC3
Clinical Information
– Phase 3
Research Area
– Neurological Disease
Solubility
– DMSO : ≥ 250 mg/mL
Target
– Beta-secretase
Isoform
– BACE1
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
