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EHT 1864 2HCl

SKU T6483-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 62 CAD through 1,573 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– EHT 1864 (EHT 1864 2HCl) is a Rac family GTPase inhibitor that blocks activation by direct binding to Rac1, Rac1b, Rac2, and Rac3 (Kd=40/50/60/250 nM). EHT 1864 inhibits Rac, Ras, and Tiam-induced growth transformation of NIH-3T3 fibroblasts.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T6483

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C25H29Cl2F3N2O4S

Citations

– 1. Weddle E A, Köseoğlu V K, DeVasure B A, et al. The type three secretion system effector protein IpgB1 promotes Shigella flexneri cell-to-cell spread through double-membrane vacuole escape. PLoS Pathogens. 2022, 18(2): e1010380 2. Liu X, Wang S, Zheng H, et al. Epimedokoreanin C, A Prenylated Flavonoid Isolated from Epimedium Koreanum, Induces Non-Apoptotic Cell Death with the Characteristics of Methuosis in Lung Cancer Cells. American Journal of Cancer Research. 2021, 11(7): 3496. 3. Liu Y, Sun Y, Xu Y, et al.Targeting VPS41 induces methuosis and inhibits autophagy in cancer cells.Cell Chemical Biology.2023 4. Zhao P, Zhang J, Song W, et al.Incarvine C and its analogues inhibit the formation of cell cytoskeleton by targeting Rac1.Bioorganic Chemistry.2024: 107512.

References

– Shutes A, et al. J Biol Chem. 2007, 282(49), 35666-35678.

CAS Number

– 754240-09-0

Molecular Weight

– C25H29Cl2F3N2O4S

Compound Purity

– 0.9918

SMILES

– Cl.Cl.FC(F)(F)c1ccc2c(SCCCCCOc3coc(CN4CCOCC4)cc3=O)ccnc2c1

Pathway

– MAPK|||Cell Cycle/Checkpoint|||GPCR/G Protein

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.