Download Files:

Ebselen

SKU T0825-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 67 CAD through 414 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 5 mg 50 mg

Clear

Products Details

Product Description

– Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced by reactive oxygen species (ROS). In addition, this agent inhibits the activity of a variety of enzymes including nitric oxide synthase (NOS), 5-lipoxygenase, cyclooxygenase, protein kinase C (PKC), NADPH oxidase and gastric H+/K+-ATPase. Furthermore, ebselen may be neuroprotective due to its ability to neutralize free radicals upon NMDA receptor activation thus, reducing lipoperoxidation mediated by glutamate-induced excitotoxicity.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T0825

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C13H9NOSe

Citations

– 1. Sakita, Karina Mayumi, et al. Efficacy of Ebselen Against Invasive Aspergillosis in a Murine Model. Frontiers in Cellular and Infection Microbiology. 11 (2021): 539. 2. Yan H, Zhang R, Yan G, et al. Production of a versatile SARS‐CoV‐2 main protease biosensor based on a dimerization‐dependent red fluorescent protein. Journal of Medical Virology. 2022 3. Li M, Bei Z C, Yuan Y, et al.In-cell bioluminescence resonance energy transfer (BRET)-based assay uncovers ceritinib and CA-074 as SARS-CoV-2 papain-like protease inhibitors.Journal of Enzyme Inhibition and Medicinal Chemistry.2024, 39(1): 2387417. 4. Wei J R, Zhang B, Zhang Y, et al.QSOX1 facilitates dormant esophageal cancer stem cells to evade immune elimination via PD-L1 upregulation and CD8 T cell exclusion.Proceedings of the National Academy of Sciences.2024, 121(44): e2407506121.

References

– Schewe T. Gen Pharmacol, 2009, 26 (6): 1153–69.

CAS Number

– 60940-34-3

Molecular Weight

– C13H9NOSe

Compound Purity

– 0.9978

SMILES

– O=C1N([Se]C=2C1=CC=CC2)C3=CC=CC=C3

Target

– Others

Pathway

– Proteases/Proteasome|||Microbiology/Virology|||Membrane transporter/Ion channel|||Immunology/Inflammation|||Neuroscience|||Metabolism

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.