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Products Details
Product Description
– Dihydroquinoline-pyrazoline DQP-997-74 (compound 2i) is a selective N-methyl-d-aspartate receptor (NMDAR) inhibitor that preferentially targets GluN2C/D subunits, with IC50 values of 0.069 μM and 0.035 μM, respectively, and possesses blood-brain barrier permeability. It enhances its inhibitory potency in a time-dependent manner when combined with the agonist glutamate, reducing epileptogenic events in a murine model of tuberous sclerosis complex (TSC)-induced epilepsy. DQP-997-74 is potentially applicable for the study of NMDAR-related neurological diseases [1].
Web ID
– T82528
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C28H19Cl2F2N3O4
CAS Number
– 2377187-09-0
Molecular Weight
– C28H19Cl2F2N3O4
SMILES
– O=C(O)CC(F)(F)C(=O)N1N=C(C=2C(=O)NC=3C=CC=CC3C2C=4C=CC(Cl)=CC4)CC1C5=CC=C(Cl)C=C5
Pathway
– Others
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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